Smart A., Hughes M.E., Downie Ruiz Velasco A., Hori N., Stolnik S., Jopling C.L. A proximity labelling-based approach to directly detect mRNA delivery to specific subcellular locations. Molecular Therapy Nucleic Acids (2025) https://doi.org/10.1016/j.omtn.2025.102602
Downie Ruiz Velasco A., Parsons A.L., Heatley M.C., Martin A.R.G., Smart A.D., Shah N., Jopling C.L. MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1. Nucleic Acids Research (2024) 52: 9210-9229 https://doi.org/10.1093/nar/gkae505
Zhuang X., Magri A., Hill M., Lai A.G., Kumar A., Rambhatla S.B., Donald C.L., Lopez-Clavijo A.F., Rudge S., Pinnick K., Chang W.H., Wing P.A.C., Brown R., Qin X., Simmonds P., Baumert T.F., Ray D., Loudon A., Balfe P., Wakelam M., Butterworth S., Kohl A., Jopling C.L., Zitzmann N., McKeating J.A. The circadian clock components BMAL1 and REV-ERBalpha regulate flavivirus replication. Nature Communications (2019) 10: 377 10.1038/s41467-019-08299-7
Ahmed C.S., Winlow P.L., Parsons A.L., Jopling C.L. Eukaryotic translation initiation factor 4AII contributes to microRNA-122 regulation of hepatitis C virus replication. Nucleic Acids Research (2018) 46: 6330-6343. https://academic.oup.com/nar/article/46/12/6330/4970503
Dhir, A., Dhir, S., Proudfoot, N.J. and Jopling, C.L. Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs. Nat. Struc. Mol. Biol. (2015) 22: 319-327. https://www.nature.com/articles/nsmb.2982
Jopling, C.L. Stop that nonsense! eLife (2014) 3:e04300. https://elifesciences.org/articles/04300
Roberts, A.P.E., Doidge, R., Tarr, A.W. and Jopling, C.L. The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122. Nuc. Acids Res. (2014) 42: 1257-1269. https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkt941
Jopling, C. Liver-specific microRNA-122: Biogenesis and function. RNA Biol. (2012) 9: 137-42. https://www.tandfonline.com/doi/abs/10.4161/rna.1887
Fletcher, N.F., Wilson, G.K., Murray, J., Hu, K. Lewis, A., Reynolds, G.M., Stamataki, Z., Meredith, L.W., Rowe, I.A., Luo, G., Lopez-Ramirez, M.A., Baumert, T.F., Weksler, B., Couraud, P.O., Kim, K.S., Romero, I.A., Jopling, C., Morgello, S., Balfe, P., and McKeating, J.A. Hepatitis C virus infection of blood-brain barrier endothelial cells. Gastroenterology (2012) 142: 634-643. https://www.sciencedirect.com/science/article/pii/S0016508511016246?via%3Dihub
Roberts, A.P.E., Lewis, A.P. and Jopling, C.L. The role of microRNAs in viral infection. Prog. Mol. Biol. Transl. Sci.(2011) 102: 101-139. https://www.sciencedirect.com/science/article/pii/B9780124157958000027?via%3Dihub
Roberts, A.P.E., Lewis, A.P. and Jopling, C.L. miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. Nuc. Acids Res. (2011) 39: 7716-7729. https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkr426
Lewis, A.P. and Jopling, C.L. Regulation and biological function of the liver-specific miR-122. Biochem. Soc. Trans.(2010) 38: 1553-7. https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST0381553
Jopling, C.L. Targeting microRNA-122 to treat hepatitis C virus infection. Viruses (2010) 2: 1382-1393. https://www.mdpi.com/1999-4915/2/7/1382. https://www.mdpi.com/1999-4915/2/7/1382
Roberts, A.P.E and Jopling, C.L. Targeting viral infection by microRNA inhibition. Genome Biol. (2010) 11: 201-204. https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-1-201
Roberts, L.O., Jopling, C.L., Jackson, R.J., and Willis, A.E. Viral strategies to subvert the mammalian translation machinery. In: Progress in Molecular Biology and Translational Science, Vol. 90, (2009) 313-367. Burlington: Academic Press. J.W.B. Hershey, editor. https://www.sciencedirect.com/science/article/pii/S1877117309900096?via%3Dihub
Spriggs, K.A., Cobbold, L.C., Jopling, C.L., Cooper, R., Wilson, L.A., Stoneley, M., Coldwell, M.J., Poncet, D., Shen, Y.C., Morley, S.J., Bushell, M. and Willis, A.E. Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Mol. Cell. Biol. (2009) 29: 1565-74. https://mcb.asm.org/content/29/6/1565.long
Jopling, C.L. Regulation of hepatitis C virus by microRNA-122. Biochem. Soc. Trans. (2008) 36: 1220-3. https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST0361220
Jopling, C.L., Schütz, S. and Sarnow, P. Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe (2008) 4: 77-85. https://www.sciencedirect.com/science/article/pii/S193131280800173X?via%3Dihub
Jopling, C.L., Norman, K.L. and Sarnow, P. Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122. Cold Spring Harb. Symp. Quant. Biol. (2006) 71: 369-76. http://symposium.cshlp.org/content/71/369.long
Sarnow, P., Jopling, C.L., Norman, K.L., Schutz, S. and Wehner, K.A. MicroRNAs: expression, avoidance and subversion by vertebrate viruses. Nat. Rev. Microbiol. (2006) 4: 651-9. https://www.nature.com/articles/nrmicro1473
Grimm, D., Streetz, K.L., Jopling, C.L., Storm, T.A., Pandey, K., Davis, C.R., Marion, P., Salazar, F. and Kay, M.A. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature (2006) 441: 537-541. https://www.nature.com/articles/nature04791
Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M. and Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science (2005) 309: 1577-1581. https://science.sciencemag.org/content/309/5740/1577.long
Jopling, C.L., Spriggs, K.A., Mitchell, S.A., Stoneley, M. and Willis, A.E. L-Myc protein synthesis is initiated by internal ribosome entry. RNA (2004) 10: 287-298. http://www.rnajournal.org/cgi/pmidlookup?view=long&pmid=14730027
Jopling, C.L. and Willis, A.E. N-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells. Oncogene (2001) 20: 2664-2670. https://www.nature.com/articles/1204404
Stoneley, M., Chappell, S.A., Jopling, C.L., Dickens, M., MacFarlane, M., and Willis, A.E. c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Mol. Cell. Biol. (2000) 20: 1162-1169. https://mcb.asm.org/content/20/4/1162.long
Stoneley, M., Subkhankulova, T., Le Quesne, J.P.C., Coldwell, M.J., Jopling, C.L., Belsham, G.J. and Willis, A.E. Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment. Nuc. Acids Res. (2000) 28: 687-694. https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/28.3.687
Jopling Lab 